/* literata-greek-opsz-normal */
@font-face {
  font-family: 'Literata Variable';
  font-style: normal;
  font-display: swap;
  font-weight: 200 900;
  src: url(../fonts/literata-greek-opsz-normal.woff2) format('woff2-variations');
  unicode-range: U+0370-0377,U+037A-037F,U+0384-038A,U+038C,U+038E-03A1,U+03A3-03FF;
}
/* literata-latin-ext-opsz-normal */
@font-face {
  font-family: 'Literata Variable';
  font-style: normal;
  font-display: swap;
  font-weight: 200 900;
  src: url(../fonts/literata-latin-ext-opsz-normal.woff2) format('woff2-variations');
  unicode-range: U+0100-02BA,U+02BD-02C5,U+02C7-02CC,U+02CE-02D7,U+02DD-02FF,U+0304,U+0308,U+0329,U+1D00-1DBF,U+1E00-1E9F,U+1EF2-1EFF,U+2020,U+20A0-20AB,U+20AD-20C0,U+2113,U+2C60-2C7F,U+A720-A7FF;
}
/* literata-latin-opsz-normal */
@font-face {
  font-family: 'Literata Variable';
  font-style: normal;
  font-display: swap;
  font-weight: 200 900;
  src: url(../fonts/literata-latin-opsz-normal.woff2) format('woff2-variations');
  unicode-range: U+0000-00FF,U+0131,U+0152-0153,U+02BB-02BC,U+02C6,U+02DA,U+02DC,U+0304,U+0308,U+0329,U+2000-206F,U+20AC,U+2122,U+2191,U+2193,U+2212,U+2215,U+FEFF,U+FFFD;
}
/* literata-greek-opsz-italic */
@font-face {
  font-family: 'Literata Variable';
  font-style: italic;
  font-display: swap;
  font-weight: 200 900;
  src: url(../fonts/literata-greek-opsz-italic.woff2) format('woff2-variations');
  unicode-range: U+0370-0377,U+037A-037F,U+0384-038A,U+038C,U+038E-03A1,U+03A3-03FF;
}
/* literata-latin-ext-opsz-italic */
@font-face {
  font-family: 'Literata Variable';
  font-style: italic;
  font-display: swap;
  font-weight: 200 900;
  src: url(../fonts/literata-latin-ext-opsz-italic.woff2) format('woff2-variations');
  unicode-range: U+0100-02BA,U+02BD-02C5,U+02C7-02CC,U+02CE-02D7,U+02DD-02FF,U+0304,U+0308,U+0329,U+1D00-1DBF,U+1E00-1E9F,U+1EF2-1EFF,U+2020,U+20A0-20AB,U+20AD-20C0,U+2113,U+2C60-2C7F,U+A720-A7FF;
}
/* literata-latin-opsz-italic */
@font-face {
  font-family: 'Literata Variable';
  font-style: italic;
  font-display: swap;
  font-weight: 200 900;
  src: url(../fonts/literata-latin-opsz-italic.woff2) format('woff2-variations');
  unicode-range: U+0000-00FF,U+0131,U+0152-0153,U+02BB-02BC,U+02C6,U+02DA,U+02DC,U+0304,U+0308,U+0329,U+2000-206F,U+20AC,U+2122,U+2191,U+2193,U+2212,U+2215,U+FEFF,U+FFFD;
}
/* commissioner-greek-wght-normal */
@font-face {
  font-family: 'Commissioner Variable';
  font-style: normal;
  font-display: swap;
  font-weight: 100 900;
  src: url(../fonts/commissioner-greek-wght-normal.woff2) format('woff2-variations');
  unicode-range: U+0370-0377,U+037A-037F,U+0384-038A,U+038C,U+038E-03A1,U+03A3-03FF;
}
/* commissioner-latin-ext-wght-normal */
@font-face {
  font-family: 'Commissioner Variable';
  font-style: normal;
  font-display: swap;
  font-weight: 100 900;
  src: url(../fonts/commissioner-latin-ext-wght-normal.woff2) format('woff2-variations');
  unicode-range: U+0100-02BA,U+02BD-02C5,U+02C7-02CC,U+02CE-02D7,U+02DD-02FF,U+0304,U+0308,U+0329,U+1D00-1DBF,U+1E00-1E9F,U+1EF2-1EFF,U+2020,U+20A0-20AB,U+20AD-20C0,U+2113,U+2C60-2C7F,U+A720-A7FF;
}
/* commissioner-latin-wght-normal */
@font-face {
  font-family: 'Commissioner Variable';
  font-style: normal;
  font-display: swap;
  font-weight: 100 900;
  src: url(../fonts/commissioner-latin-wght-normal.woff2) format('woff2-variations');
  unicode-range: U+0000-00FF,U+0131,U+0152-0153,U+02BB-02BC,U+02C6,U+02DA,U+02DC,U+0304,U+0308,U+0329,U+2000-206F,U+20AC,U+2122,U+2191,U+2193,U+2212,U+2215,U+FEFF,U+FFFD;
}

/* cverros.gr — design system
   Palette drawn from an H&E-stained skin section:
   hematoxylin (nuclei, indigo-violet) for structure, eosin (cytoplasm, pink) as accent. */

:root {
  --slide: #F5FBFE;        /* page: pale sky */
  --paper: #FFFFFF;
  --ink: #103245;          /* text */
  --ink-2: #2E4E60;
  --muted: #557080;
  --hema: #0B5C78;         /* primary: deep petrol blue */
  --hema-deep: #072F46;
  --hema-tint: #E2F4FA;
  --eosin: #0A7C91;        /* accent: the original cverros teal, darkened for AA */
  --eosin-tint: #D3F0F8;
  --eosin-wash: #EEFAFD;
  --line: #D7ECF3;
  --line-2: #C2E1EC;

  --he-sky: var(--slide);
  --he-epi: #CDEAF3;
  --he-dermis: #EAF6FA;
  --he-collagen: #BEE0EC;
  --he-corneum: #94D0E2;
  --he-nucleus: #0E4E6E;
  --he-nucleus-pale: #5FA6C4;
  --he-rbc: #22B8D6;

  --serif: "Literata Variable", "Literata", Georgia, "Times New Roman", serif;
  --sans: "Commissioner Variable", "Commissioner", "Segoe UI", system-ui, -apple-system, sans-serif;

  --wrap: 1180px;
  --gutter: clamp(16px, 4vw, 40px);
  --radius-s: 6px;
  --radius-m: 12px;
  --header-h: 76px;
}

*, *::before, *::after { box-sizing: border-box; }
html { -webkit-text-size-adjust: 100%; scroll-padding-top: calc(var(--header-h) + 16px); }
body {
  margin: 0;
  background: var(--slide);
  color: var(--ink);
  font-family: var(--sans);
  font-size: 16px;
  line-height: 1.6;
  font-optical-sizing: auto;
  text-rendering: optimizeLegibility;
}
img { max-width: 100%; height: auto; display: block; }
a { color: var(--hema); text-decoration-thickness: 1px; text-underline-offset: 3px; }
a:hover { color: var(--eosin); }
:focus-visible { outline: 3px solid var(--eosin); outline-offset: 2px; border-radius: 3px; }
::selection { background: var(--eosin-tint); color: var(--ink); }

.wrap { max-width: var(--wrap); margin: 0 auto; padding: 0 var(--gutter); }
.skip { position: absolute; left: -9999px; top: 0; background: var(--hema); color: #fff; padding: 10px 16px; z-index: 100; }
.skip:focus { left: 12px; top: 12px; }
.visually-hidden { position: absolute !important; width: 1px; height: 1px; overflow: hidden; clip: rect(0 0 0 0); white-space: nowrap; }

/* ---------- Header ---------- */
.site-header {
  position: sticky; top: 0; z-index: 40;
  background: rgba(255, 255, 255, 0.96);
  backdrop-filter: saturate(1.4) blur(8px);
  border-bottom: 1px solid var(--line);
}
.site-header .wrap { display: flex; align-items: center; gap: 24px; min-height: var(--header-h); }
.brand { display: flex; flex-direction: column; text-decoration: none; color: var(--ink); line-height: 1.15; margin-right: auto; }
.brand:hover { color: var(--ink); }
.brand-name { font-family: var(--serif); font-weight: 600; font-size: 1.28rem; letter-spacing: -0.005em; }
.brand-role { font-size: 0.86rem; color: var(--muted); margin-top: 3px; }

.nav { display: flex; align-items: center; gap: 4px; }
.nav > a, .nav-group > button {
  font: inherit; font-size: 0.95rem; color: var(--ink-2); text-decoration: none;
  padding: 9px 12px; border-radius: var(--radius-s); background: none; border: 0; cursor: pointer;
  display: inline-flex; align-items: center; gap: 6px; white-space: nowrap;
}
.brand-name, .brand-role { white-space: nowrap; }
.nav > a.nav-home { display: none; }
.nav > a:hover, .nav-group > button:hover { background: var(--hema-tint); color: var(--hema-deep); }
.nav a[aria-current="page"], .nav-group.is-current > button { color: var(--hema-deep); font-weight: 600; }
.nav a[aria-current="page"]:not(.nav-cta) { box-shadow: inset 0 -2px 0 var(--eosin); border-radius: 0; }
.nav .nav-cta { background: var(--hema); color: #fff; font-weight: 600; margin-left: 8px; padding: 10px 16px; }
.nav .nav-cta:hover { background: var(--hema-deep); color: #fff; }
.nav .nav-cta[aria-current="page"] { box-shadow: none; border-radius: var(--radius-s); color: #fff; }
.caret { width: 10px; height: 10px; transition: transform .2s; }
.nav-group { position: relative; }
.nav-group > button[aria-expanded="true"] .caret { transform: rotate(180deg); }
.nav-panel {
  position: absolute; top: calc(100% + 10px); left: 50%; transform: translateX(-50%);
  width: min(560px, 92vw); background: var(--paper); border: 1px solid var(--line);
  border-radius: var(--radius-m); box-shadow: 0 18px 40px -18px rgba(7, 47, 70, 0.30);
  padding: 18px; display: none; grid-template-columns: 1fr 1fr; gap: 6px 22px;
}
.nav-group.open .nav-panel { display: grid; }
.nav-panel a { display: block; padding: 8px 10px; border-radius: var(--radius-s); text-decoration: none; color: var(--ink); }
.nav-panel a:hover { background: var(--hema-tint); color: var(--hema-deep); }
.nav-panel a small { display: block; color: var(--muted); font-size: 0.82rem; line-height: 1.35; margin-top: 2px; }
.nav-panel .panel-title { font-size: 0.82rem; color: var(--eosin); font-weight: 600; padding: 4px 10px 2px; }
.nav-panel .panel-col { display: flex; flex-direction: column; gap: 2px; }

.menu-toggle { display: none; }

@media (max-width: 1300px) {
  :root { --header-h: 64px; }
  .nav > a.nav-home { display: inline-flex; }
  .site-header { backdrop-filter: none; background: #fff; }
  .brand-name { font-size: 1.08rem; }
  .brand-role { font-size: 0.8rem; }
  .menu-toggle {
    display: inline-flex; align-items: center; gap: 8px; font: inherit; font-weight: 600; font-size: 0.95rem;
    background: var(--hema-tint); color: var(--hema-deep); border: 0; border-radius: var(--radius-s); padding: 10px 14px; cursor: pointer;
  }
  .nav {
    position: fixed; inset: var(--header-h) 0 0 0; background: var(--paper);
    flex-direction: column; align-items: stretch; gap: 0; padding: 12px var(--gutter) 40px;
    overflow-y: auto; display: none; border-top: 1px solid var(--line);
  }
  body.menu-open { overflow: hidden; }
  body.menu-open .nav { display: flex; }
  .nav > a, .nav-group > button { font-size: 1.08rem; padding: 14px 4px; border-bottom: 1px solid var(--line); border-radius: 0; width: 100%; justify-content: space-between; }
  .nav a[aria-current="page"]:not(.nav-cta) { box-shadow: inset 3px 0 0 var(--eosin); padding-left: 12px; }
  .nav .nav-cta { margin: 20px 0 0; justify-content: center; border-radius: var(--radius-s); border-bottom: 0; }
  .nav-panel { position: static; transform: none; width: auto; box-shadow: none; border: 0; padding: 6px 0 12px 8px; grid-template-columns: 1fr; }
}

/* ---------- Generic page structure ---------- */
main { display: block; }
.page-head { padding: clamp(36px, 6vw, 72px) 0 clamp(24px, 3vw, 36px); }
.page-head .crumbs { font-size: 0.9rem; color: var(--muted); margin: 0 0 14px; }
.page-head .crumbs a { color: var(--muted); }
.page-head h1 {
  font-family: var(--serif); font-weight: 600; letter-spacing: -0.012em;
  font-size: clamp(2rem, 4.2vw, 3.1rem); line-height: 1.12; margin: 0; max-width: 22ch; text-wrap: balance;
}
.page-head .lede { font-size: clamp(1.05rem, 1.6vw, 1.2rem); color: var(--ink-2); max-width: 62ch; margin: 18px 0 0; }
.page-head.wide h1 { max-width: 30ch; }
.rule-eosin { width: 56px; height: 3px; background: var(--eosin); border: 0; margin: 0 0 22px; border-radius: 2px; }

h2, h3 { text-wrap: balance; }
.section { padding: clamp(36px, 5vw, 64px) 0; }
.section + .section { border-top: 1px solid var(--line); }
.section-title { font-family: var(--serif); font-weight: 600; font-size: clamp(1.5rem, 2.6vw, 2rem); line-height: 1.2; margin: 0 0 8px; letter-spacing: -0.008em; }
.section-sub { color: var(--muted); margin: 0 0 28px; max-width: 60ch; }

.btn {
  display: inline-flex; align-items: center; justify-content: center; gap: 8px; min-height: 46px;
  padding: 11px 20px; border-radius: var(--radius-s); font-weight: 600; font-size: 0.98rem; text-decoration: none;
  border: 1.5px solid var(--hema); background: var(--hema); color: #fff; cursor: pointer; font-family: var(--sans);
}
.btn:hover { background: var(--hema-deep); border-color: var(--hema-deep); color: #fff; }
.btn.secondary { background: transparent; color: var(--hema); }
.btn.secondary:hover { background: var(--hema-tint); color: var(--hema-deep); }

/* ---------- Home ---------- */
.hero { padding: clamp(36px, 6vw, 80px) 0 0; position: relative; }
.hero-grid { display: grid; grid-template-columns: 1.25fr 0.9fr; gap: clamp(28px, 5vw, 72px); align-items: end; }
.hero-kicker { color: var(--eosin); font-weight: 600; font-size: 1rem; margin: 0 0 14px; }
.hero h1 {
  font-family: var(--serif); font-weight: 560; letter-spacing: -0.022em; line-height: 0.98;
  font-size: clamp(2.9rem, 7.4vw, 6rem); margin: 0; color: var(--hema-deep);
}
.hero h1 span { display: block; }
.hero-text { font-size: clamp(1.05rem, 1.5vw, 1.2rem); color: var(--ink-2); max-width: 54ch; margin: 26px 0 30px; }
.hero-actions { display: flex; flex-wrap: wrap; gap: 12px; }
.hero-figure { margin: 0; position: relative; padding-bottom: 28px; }
.hero-figure img { width: 100%; aspect-ratio: 5 / 4; object-fit: cover; border-radius: 180px 180px var(--radius-m) var(--radius-m); border: 1px solid var(--line); background: var(--hema-tint); }
.hero-figure figcaption { font-size: 0.85rem; color: var(--muted); margin-top: 10px; }
.band-wrap { margin-top: clamp(28px, 4vw, 48px); line-height: 0; overflow: hidden; }
.skin-band { width: 100%; height: clamp(150px, 16vw, 230px); display: block; }
.skin-band--thin { height: 64px; }
.band-caption { font-size: 0.84rem; color: var(--muted); padding-top: 10px; line-height: 1.4; }

.topic-index { display: grid; grid-template-columns: repeat(3, 1fr); gap: 34px 40px; }
.topic-group h3 { font-family: var(--serif); font-size: 1.18rem; font-weight: 600; margin: 0 0 10px; padding-bottom: 10px; border-bottom: 1px solid var(--line-2); }
.topic-group ul { list-style: none; margin: 0; padding: 0; }
.topic-group li a { display: block; padding: 7px 0; text-decoration: none; color: var(--ink); border-bottom: 1px dashed var(--line); }
.topic-group li a:hover { color: var(--eosin); }

.split { display: grid; grid-template-columns: 1fr 1fr; gap: clamp(28px, 5vw, 64px); }
.feature-pub { border-left: 3px solid var(--eosin); padding: 4px 0 4px 20px; margin: 0 0 22px; }
.feature-pub .journal { font-family: var(--serif); font-style: italic; font-size: 1.15rem; color: var(--hema-deep); }
.feature-pub p { margin: 4px 0 0; color: var(--ink-2); }
.heritage { background: var(--hema-deep); color: #E2F4FA; border-radius: var(--radius-m); padding: clamp(24px, 3.5vw, 40px); position: relative; overflow: hidden; }
.heritage h2 { font-family: var(--serif); font-weight: 560; font-size: clamp(1.5rem, 2.4vw, 1.9rem); margin: 0 0 12px; color: #fff; }
.heritage p { margin: 0 0 14px; max-width: 52ch; }
.heritage .year { font-family: var(--serif); font-size: clamp(4rem, 9vw, 7rem); line-height: 0.9; color: rgba(223, 248, 255, 0.14); position: absolute; right: 18px; bottom: 6px; font-weight: 700; letter-spacing: -0.03em; pointer-events: none; }
.heritage a { color: #fff; }

/* ---------- Patients index ---------- */
.finder { display: flex; gap: 12px; align-items: center; margin-top: 26px; max-width: 560px; }
.finder input {
  flex: 1; font: inherit; font-size: 1.02rem; padding: 13px 16px 13px 44px; border-radius: var(--radius-s);
  border: 1.5px solid var(--line-2); background: var(--paper) url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='20' height='20' fill='none' stroke='%23625F7E' stroke-width='2' stroke-linecap='round'%3E%3Ccircle cx='8.5' cy='8.5' r='6'/%3E%3Cpath d='m13 13 5 5'/%3E%3C/svg%3E") no-repeat 14px center;
  color: var(--ink);
}
.finder input:focus { border-color: var(--hema); outline: none; box-shadow: 0 0 0 3px var(--hema-tint); }
.finder-empty { display: none; padding: 18px 20px; border-radius: var(--radius-s); background: var(--eosin-wash); border: 1px solid var(--eosin-tint); margin-bottom: 28px; }
.finder-empty.show { display: block; }
.cat-grid { display: grid; grid-template-columns: repeat(2, 1fr); gap: 44px 56px; padding-bottom: 64px; }
.cat h2 { font-family: var(--serif); font-weight: 600; font-size: 1.45rem; margin: 0 0 4px; }
.cat > p { color: var(--muted); margin: 0 0 14px; font-size: 0.95rem; }
.cat ul { list-style: none; margin: 0; padding: 0; border-top: 1px solid var(--line-2); }
.cat li { border-bottom: 1px solid var(--line); }
.cat li a { display: block; padding: 13px 0; text-decoration: none; color: var(--ink); }
.cat li a strong { display: block; font-weight: 600; font-size: 1.03rem; }
.cat li a span { display: block; color: var(--muted); font-size: 0.92rem; line-height: 1.45; margin-top: 2px; }
.cat li a:hover strong { color: var(--eosin); }

/* ---------- Article ---------- */
.article-layout { display: grid; grid-template-columns: minmax(0, 1fr) 280px; gap: clamp(32px, 5vw, 72px); padding-bottom: 72px; }
.article-layout.no-aside { grid-template-columns: minmax(0, 1fr); }
.prose { font-family: var(--serif); font-size: 1.125rem; line-height: 1.75; color: var(--ink); max-width: 68ch; }
.prose.wide { max-width: none; }
.prose > *:first-child { margin-top: 0; }
.prose p { margin: 0 0 1.05em; }
.prose h2 { font-family: var(--serif); font-weight: 600; font-size: 1.6rem; line-height: 1.25; margin: 2em 0 0.6em; color: var(--hema-deep); letter-spacing: -0.006em; }
.prose h3 { font-family: var(--sans); font-weight: 650; font-size: 1.12rem; line-height: 1.35; margin: 1.7em 0 0.5em; color: var(--ink); }
.prose h2 + h3 { margin-top: 0.8em; }
.prose ul, .prose ol { padding-left: 1.3em; margin: 0 0 1.1em; }
.prose li { margin: 0.35em 0; padding-left: 0.2em; }
.prose li::marker { color: var(--eosin); }
.prose ol li::marker { font-family: var(--sans); font-weight: 600; font-size: 0.92em; }
.prose strong { font-weight: 650; }
.prose a { word-break: break-word; }
.prose .byline { font-family: var(--sans); font-size: 0.95rem; color: var(--muted); margin-bottom: 1.6em; }
.figs { display: grid; gap: 12px; margin: 1.6em 0 1.8em; grid-template-columns: repeat(var(--n, 1), minmax(0, 1fr)); align-items: start; }
.figs.n1 { --n: 1; max-width: 560px; }
.figs.n1.small { max-width: 340px; }
.figs.n2 { --n: 2; }
.figs.n3 { --n: 3; }
.figs.n4, .figs.n5, .figs.n6 { --n: 3; }
.figs > a { display: block; border-radius: var(--radius-s); overflow: hidden; border: 1px solid var(--line); background: var(--paper); cursor: zoom-in; }
.figs img { width: 100%; height: auto; }
.figs.cropped img { aspect-ratio: 4 / 3; object-fit: cover; }
.prose .note {
  font-family: var(--sans); font-size: 0.95rem; line-height: 1.6; background: var(--hema-tint); border-radius: var(--radius-s);
  padding: 16px 18px; margin: 2.2em 0 0; color: var(--ink-2);
}
.prose .note.archive { background: var(--eosin-wash); border: 1px solid var(--eosin-tint); margin: 0 0 1.8em; }
.table-wrap { overflow-x: auto; margin: 1.4em 0 1.8em; border: 1px solid var(--line); border-radius: var(--radius-s); background: var(--paper); }
.table-wrap table { border-collapse: collapse; width: 100%; font-family: var(--sans); font-size: 0.95rem; line-height: 1.45; }
.table-wrap caption { text-align: left; font-weight: 600; padding: 12px 14px 4px; color: var(--hema-deep); }
.table-wrap th, .table-wrap td { padding: 9px 14px; border-bottom: 1px solid var(--line); text-align: left; vertical-align: top; }
.table-wrap th { background: var(--hema-tint); color: var(--hema-deep); font-weight: 600; white-space: nowrap; }
.table-wrap td.num, .table-wrap th.num { text-align: right; font-variant-numeric: tabular-nums; white-space: nowrap; }
.table-wrap tr:last-child td { border-bottom: 0; }
.table-wrap tr.total td { font-weight: 650; background: var(--eosin-wash); }
.table-note { font-family: var(--sans); font-size: 0.88rem; color: var(--muted); margin-top: -1em !important; }
.video { position: relative; aspect-ratio: 16 / 9; margin: 1.6em 0; border-radius: var(--radius-s); overflow: hidden; background: #000; }
.video iframe { position: absolute; inset: 0; width: 100%; height: 100%; border: 0; }

.aside { font-size: 0.95rem; }
.aside-block { position: sticky; top: calc(var(--header-h) + 24px); display: flex; flex-direction: column; gap: 28px; }
.aside h2 { font-family: var(--sans); font-size: 0.9rem; font-weight: 650; color: var(--eosin); margin: 0 0 10px; }
.aside ol, .aside ul { list-style: none; margin: 0; padding: 0; border-left: 1px solid var(--line-2); }
.aside li a { display: block; padding: 6px 0 6px 14px; color: var(--ink-2); text-decoration: none; line-height: 1.35; margin-left: -1px; border-left: 2px solid transparent; }
.aside li a:hover { color: var(--hema-deep); }
.aside li a.active { border-left-color: var(--eosin); color: var(--hema-deep); font-weight: 600; }

.article-foot { border-top: 1px solid var(--line); margin-top: 3em; padding-top: 1.6em; font-family: var(--sans); }
.article-foot .disclaimer { font-size: 0.9rem; color: var(--muted); max-width: 64ch; }
.related { margin-top: 1.6em; }
.related h2 { font-family: var(--serif); font-size: 1.25rem; margin: 0 0 10px; color: var(--ink); font-weight: 600; }
.related ul { list-style: none; padding: 0; margin: 0; display: grid; grid-template-columns: repeat(2, 1fr); gap: 0 28px; }
.related li a { display: block; padding: 9px 0; border-bottom: 1px solid var(--line); text-decoration: none; color: var(--ink); }
.related li a:hover { color: var(--eosin); }

/* ---------- Lightbox ---------- */
dialog.lightbox { border: 0; padding: 0; background: transparent; max-width: 94vw; max-height: 92vh; }
dialog.lightbox::backdrop { background: rgba(4, 28, 42, 0.86); }
dialog.lightbox img { max-width: 94vw; max-height: 86vh; width: auto; border-radius: var(--radius-s); }
dialog.lightbox button { position: fixed; top: 14px; right: 14px; font: inherit; font-weight: 600; background: #fff; color: var(--ink); border: 0; border-radius: var(--radius-s); padding: 10px 14px; cursor: pointer; }

/* ---------- Contact ---------- */
.contact-grid { display: grid; grid-template-columns: minmax(0, 0.95fr) minmax(0, 1.05fr); gap: clamp(28px, 4vw, 56px); padding-bottom: 72px; align-items: start; }
.info-block { padding: 22px 0; border-top: 1px solid var(--line-2); }
.info-block:first-child { border-top: 0; padding-top: 0; }
.info-block h2 { font-family: var(--sans); font-size: 0.92rem; color: var(--eosin); font-weight: 650; margin: 0 0 8px; }
.info-block p { margin: 0 0 6px; }
.info-block .big { font-family: var(--serif); font-size: clamp(1.35rem, 2.4vw, 1.7rem); font-weight: 560; color: var(--hema-deep); line-height: 1.3; }
.info-block .big a { text-decoration: none; color: var(--hema-deep); }
.info-block .big a:hover { color: var(--eosin); }
.info-block .muted { color: var(--muted); font-size: 0.95rem; }
.hours { width: 100%; border-collapse: collapse; margin-top: 4px; }
.hours th, .hours td { text-align: left; padding: 10px 0; border-bottom: 1px solid var(--line); vertical-align: top; }
.hours th { font-family: var(--serif); font-size: 1.15rem; font-weight: 600; color: var(--hema-deep); width: 6.2em; }
.hours td .tag { display: inline-block; font-size: 0.86rem; font-weight: 600; padding: 3px 10px; border-radius: 999px; margin-top: 6px; }
.tag.walkin { background: var(--hema-tint); color: var(--hema-deep); }
.tag.appt { background: #FFF1D6; color: #7A4A00; }
.no-appt { background: var(--hema-tint); border-radius: var(--radius-s); padding: 16px 18px; margin-top: 16px; }
.no-appt p { margin: 0 0 6px; font-weight: 600; color: var(--hema-deep); }
.no-appt ul { margin: 0; padding-left: 1.2em; }
.booking { background: var(--paper); border: 1px solid var(--line); border-radius: var(--radius-m); overflow: hidden; box-shadow: 0 24px 50px -32px rgba(7, 47, 70, 0.30); }
.booking-head { padding: 18px 22px; border-bottom: 1px solid var(--line); background: var(--hema-deep); color: #fff; }
.booking-head h2 { margin: 0; font-family: var(--serif); font-weight: 560; font-size: 1.35rem; }
.booking-head p { margin: 4px 0 0; color: #CBE8F1; font-size: 0.93rem; }
.booking iframe { display: block; width: 100%; height: 1020px; border: 0; background: var(--paper); }
.booking-foot { padding: 12px 22px 16px; font-size: 0.9rem; color: var(--muted); border-top: 1px solid var(--line); }

/* ---------- Bio ---------- */
.bio-hero { display: grid; grid-template-columns: 1.2fr 0.8fr; gap: clamp(28px, 5vw, 72px); align-items: end; padding: clamp(36px, 6vw, 72px) 0 clamp(28px, 4vw, 48px); }
.bio-hero h1 { font-family: var(--serif); font-weight: 560; font-size: clamp(2.4rem, 5.4vw, 4.2rem); line-height: 1.02; letter-spacing: -0.02em; margin: 0; color: var(--hema-deep); }
.bio-hero .creds { font-size: 1.15rem; color: var(--ink-2); margin: 14px 0 0; }
.bio-hero .lede { font-size: 1.1rem; color: var(--ink-2); max-width: 54ch; margin: 22px 0 0; }
.portrait { margin: 0; }
.portrait img { width: 100%; aspect-ratio: 4 / 5; object-fit: cover; object-position: 50% 30%; border-radius: 999px 999px var(--radius-m) var(--radius-m); border: 1px solid var(--line); }
.timeline { list-style: none; margin: 0; padding: 0; position: relative; }
.timeline li { display: grid; grid-template-columns: 9.5em minmax(0, 1fr); gap: 22px; padding: 16px 0; border-bottom: 1px solid var(--line); }
.timeline .when { font-family: var(--serif); font-weight: 600; color: var(--eosin); font-variant-numeric: tabular-nums; }
.timeline .what { color: var(--ink); }
.cols-2 { display: grid; grid-template-columns: 1fr 1fr; gap: clamp(28px, 5vw, 64px); }
.plain-list { list-style: none; padding: 0; margin: 0; }
.plain-list li { padding: 12px 0; border-bottom: 1px solid var(--line); }
.plain-list li:first-child { border-top: 1px solid var(--line-2); }
.plain-list li small { display: block; color: var(--muted); font-size: 0.92rem; }

/* ---------- Publications ---------- */
.pubs { list-style: none; margin: 0 0 12px; padding: 0; }
.pubs li { display: grid; grid-template-columns: 4.2em minmax(0, 1fr); gap: 18px; padding: 14px 0; border-bottom: 1px solid var(--line); line-height: 1.55; }
.pubs li .y { font-family: var(--serif); font-weight: 600; color: var(--eosin); font-variant-numeric: tabular-nums; }
.pubs li.star { background: linear-gradient(90deg, var(--eosin-wash), transparent 70%); }
.pubs li em { font-style: italic; }
.pubs li .t { font-family: var(--serif); }
.jump { display: flex; flex-wrap: wrap; gap: 8px; margin: 22px 0 0; padding: 0; list-style: none; }
.jump a { display: inline-block; padding: 7px 14px; border: 1px solid var(--line-2); border-radius: 999px; text-decoration: none; font-size: 0.93rem; color: var(--ink-2); background: var(--paper); }
.jump a:hover { border-color: var(--hema); color: var(--hema-deep); }

/* ---------- Dermatologists hub ---------- */
.hub { display: grid; grid-template-columns: repeat(2, 1fr); gap: 0 56px; padding-bottom: 72px; }
.hub-item { padding: 26px 0; border-top: 1px solid var(--line-2); }
.hub-item h2 { font-family: var(--serif); font-weight: 600; font-size: 1.4rem; margin: 0 0 6px; }
.hub-item h2 a { text-decoration: none; color: var(--hema-deep); }
.hub-item h2 a:hover { color: var(--eosin); }
.hub-item p { margin: 0 0 8px; color: var(--ink-2); }
.hub-item ul { margin: 6px 0 0; padding-left: 1.1em; }
.hub-item li { margin: 3px 0; }
.hub-item li::marker { color: var(--eosin); }

/* ---------- Drug reference ---------- */
.dref-tools { position: sticky; top: var(--header-h); z-index: 5; background: var(--slide); padding: 14px 0; border-bottom: 1px solid var(--line); margin-bottom: 8px; }
.dref-tools .finder { margin-top: 0; max-width: none; }
.letters { display: flex; flex-wrap: wrap; gap: 4px; margin-top: 10px; font-family: var(--sans); }
.letters a { min-width: 30px; text-align: center; padding: 4px 6px; border-radius: 4px; text-decoration: none; font-weight: 600; font-size: 0.9rem; color: var(--hema); background: var(--hema-tint); }
.letters a:hover { background: var(--hema); color: #fff; }
dl.dref { margin: 0; font-family: var(--sans); font-size: 0.98rem; }
dl.dref .entry { display: grid; grid-template-columns: 15em minmax(0, 1fr); gap: 18px; padding: 12px 0; border-bottom: 1px solid var(--line); }
dl.dref dt { font-weight: 650; color: var(--hema-deep); font-family: var(--serif); font-size: 1.04rem; }
dl.dref dd { margin: 0; color: var(--ink-2); line-height: 1.6; }
dl.dref dd ul { margin: 0; padding-left: 1.1em; }
dl.dref .letter-head { font-family: var(--serif); font-size: 1.8rem; color: var(--eosin); font-weight: 600; padding: 22px 0 4px; border-bottom: 2px solid var(--eosin-tint); }
mark { background: #FBE7A6; color: inherit; padding: 0 1px; border-radius: 2px; }

/* ---------- AIDS dossier ---------- */
.chart { margin: 1.4em 0 2em; font-family: var(--sans); }
.chart-bars { display: grid; grid-auto-flow: column; grid-auto-columns: 1fr; align-items: end; gap: 6px; height: 240px; border-bottom: 1px solid var(--line-2); padding: 0 2px; }
.chart-bars .bar { position: relative; background: var(--hema); border-radius: 3px 3px 0 0; min-height: 2px; }
.chart-bars .bar.hi { background: #22B8D6; }
.chart-bars .bar span { position: absolute; top: -20px; left: 50%; transform: translateX(-50%); font-size: 0.74rem; color: var(--ink-2); font-variant-numeric: tabular-nums; white-space: nowrap; }
.chart-axis { display: grid; grid-auto-flow: column; grid-auto-columns: 1fr; gap: 6px; padding: 6px 2px 0; }
.chart-axis span { font-size: 0.72rem; color: var(--muted); text-align: center; font-variant-numeric: tabular-nums; white-space: nowrap; overflow: hidden; }
.chart figcaption { font-size: 0.9rem; color: var(--muted); margin-top: 10px; }
.dossier { list-style: none; padding: 0; margin: 0; counter-reset: none; }
.dossier li { border-top: 1px solid var(--line-2); }
.dossier a { display: grid; grid-template-columns: 4.6em minmax(0, 1fr); gap: 16px; padding: 16px 0; text-decoration: none; color: var(--ink); }
.dossier .yr { font-family: var(--serif); font-weight: 600; color: var(--eosin); }
.dossier strong { display: block; font-family: var(--serif); font-size: 1.12rem; font-weight: 600; color: var(--hema-deep); }
.dossier span.d { display: block; color: var(--muted); font-size: 0.94rem; margin-top: 2px; }
.dossier a:hover strong { color: var(--eosin); }
.stat-row { display: grid; grid-template-columns: repeat(3, 1fr); gap: 0; border-top: 1px solid var(--line-2); border-bottom: 1px solid var(--line-2); margin: 1.6em 0; font-family: var(--sans); }
.stat-row div { padding: 16px 16px 16px 0; }
.stat-row div + div { border-left: 1px solid var(--line); padding-left: 16px; }
.stat-row b { display: block; font-family: var(--serif); font-size: 1.9rem; font-weight: 600; color: var(--hema-deep); line-height: 1.1; }
.stat-row span { font-size: 0.9rem; color: var(--muted); }

/* ---------- News ---------- */
.news h2 { scroll-margin-top: calc(var(--header-h) + 16px); }
.news .year-head { display: flex; align-items: baseline; gap: 16px; border-bottom: 2px solid var(--eosin-tint); padding-bottom: 8px; margin: 2.2em 0 1em; }
.news .year-head b { font-family: var(--serif); font-size: 2.6rem; color: var(--eosin); line-height: 1; }
.news .year-head span { font-family: var(--sans); color: var(--muted); }

/* ---------- Footer ---------- */
.site-footer { margin-top: 0; background: var(--hema-deep); color: #D3EAF2; }
.site-footer .skin-band { --he-sky: var(--slide); }
.footer-grid { display: grid; grid-template-columns: 1.3fr 1fr 1fr; gap: 36px; padding: 44px 0 30px; }
.site-footer h2 { font-family: var(--sans); font-size: 0.9rem; font-weight: 650; color: #9FDDEB; margin: 0 0 12px; }
.site-footer .f-brand { font-family: var(--serif); font-size: 1.3rem; color: #fff; font-weight: 560; margin: 0 0 6px; }
.site-footer p { margin: 0 0 6px; }
.site-footer a { color: #fff; text-decoration-color: rgba(255,255,255,.35); }
.site-footer a:hover { color: #9FDDEB; }
.site-footer ul { list-style: none; padding: 0; margin: 0; }
.site-footer li { margin: 0 0 7px; }
.footer-base { border-top: 1px solid rgba(255,255,255,0.14); padding: 16px 0 26px; font-size: 0.86rem; color: #A8CAD7; display: flex; flex-wrap: wrap; justify-content: space-between; gap: 10px; }

/* ---------- 404 ---------- */
.notfound { padding: 80px 0 100px; }

/* ---------- Responsive ---------- */
@media (max-width: 1020px) {
  .article-layout { grid-template-columns: minmax(0, 1fr); }
  .aside { order: -1; }
  .aside-block { position: static; }
  .aside .toc-block { display: none; }
  .aside .rel-block { display: none; }
  .topic-index { grid-template-columns: repeat(2, 1fr); }
}
@media (max-width: 760px) {
  .hero-grid, .split, .cols-2, .bio-hero, .contact-grid, .hub, .cat-grid { grid-template-columns: minmax(0, 1fr); }
  .hero-figure { order: -1; max-width: 420px; padding-bottom: 0; }
  .hero h1 { font-size: clamp(2.6rem, 12vw, 3.6rem); }
  .topic-index { grid-template-columns: minmax(0, 1fr); }
  .portrait { max-width: 320px; order: -1; }
  .timeline li { grid-template-columns: minmax(0, 1fr); gap: 2px; }
  .pubs li { grid-template-columns: 3.4em minmax(0, 1fr); gap: 12px; }
  .footer-grid { grid-template-columns: minmax(0, 1fr); gap: 26px; }
  .related ul { grid-template-columns: minmax(0, 1fr); }
  .figs.n3, .figs.n4, .figs.n5, .figs.n6 { --n: 2; }
  .prose { font-size: 1.07rem; }
  dl.dref .entry { grid-template-columns: minmax(0, 1fr); gap: 4px; }
  .booking iframe { height: 1180px; }
  .stat-row { grid-template-columns: minmax(0, 1fr); }
  .stat-row div + div { border-left: 0; border-top: 1px solid var(--line); padding-left: 0; }
  .chart-bars { height: 180px; gap: 3px; }
  .chart-bars .bar span { display: none; }
  .chart-axis { gap: 3px; }
  .chart-axis span { font-size: 0.6rem; writing-mode: vertical-rl; transform: rotate(180deg); height: 3.2em; }
}

@media (prefers-reduced-motion: no-preference) {
  .skin-band--full .junction-draw { stroke-dasharray: 3000; stroke-dashoffset: 3000; animation: draw 2.4s ease-out .2s forwards; }
  @keyframes draw { to { stroke-dashoffset: 0; } }
}

@media print {
  .site-header, .site-footer, .aside, .skip, .article-foot .related, .band-wrap { display: none !important; }
  body { background: #fff; }
  .prose { max-width: none; font-size: 11pt; }
  a { color: inherit; }
}
.table-wrap th[colspan] { text-align: center; }
.table-wrap tr + tr th { background: var(--hema-tint); }
.news h3 { font-family: var(--serif); font-size: 1.35rem; font-weight: 600; color: var(--hema-deep); margin-top: 2.2em; }
.pubs li { grid-template-columns: 5.4em minmax(0, 1fr); }
.figs figcaption { grid-column: 1 / -1; font-family: var(--sans); font-size: 0.9rem; color: var(--muted); margin-top: 2px; }
.figs img { max-height: 520px; width: auto; margin: 0 auto; }

.booking-start { padding: 28px 22px; }
.booking-start .btn { width: 100%; white-space: normal; text-align: center; line-height: 1.35; padding: 16px 20px; font-size: 1.02rem; }
.booking-frame[hidden] { display: none; }

/* «Σύντομα» — πριν ενεργοποιηθεί η online κράτηση */
.soon-badge { display: inline-block; margin-bottom: 6px; padding: 3px 10px; border-radius: 999px; background: #22B8D6; color: #072F46; font-size: 0.78rem; font-weight: 650; letter-spacing: 0.04em; text-transform: uppercase; }
.booking-soon { padding: 24px 22px 26px; }
.booking-soon p { margin: 0 0 12px; font-size: 1.02rem; line-height: 1.6; }
.booking-soon p:last-child { margin-bottom: 0; }
.booking-soon a { font-weight: 600; white-space: nowrap; }

/* Αρχική χωρίς φωτογραφία (η φωτογραφία μόνο στο βιογραφικό) */
.hero-grid.hero-solo { grid-template-columns: minmax(0, 1fr); }
.hero-grid.hero-solo > div { max-width: 46rem; }

/* Υποσημειώσεις */
.footnote { font-size: 0.84rem; color: var(--muted); margin-top: 14px; }
.heritage .footnote { color: #9CC9D8; margin-top: 4px; }
sup { font-size: 0.7em; line-height: 0; }

/* Μενού: Θεραπευτικές εξελίξεις τονισμένες, μονόστηλο panel */
.nav-badge { display: inline-block; margin-left: 4px; padding: 1px 7px; border-radius: 999px; background: #22B8D6; color: #072F46; font-size: 0.72rem; font-weight: 700; line-height: 1.5; vertical-align: 1px; }
.nav > a.nav-news { color: var(--hema-deep); font-weight: 600; }
.nav-panel.one { width: min(300px, 92vw); grid-template-columns: 1fr; }

/* Αρχική: ζώνη Θεραπευτικών εξελίξεων */
.news-band { background: var(--hema-deep); color: #E2F4FA; padding: clamp(36px, 5vw, 60px) 0; }
.news-band-head { max-width: 46rem; margin-bottom: 26px; }
.news-band-kicker { margin: 0 0 6px; color: #22B8D6; font-weight: 650; font-size: 0.85rem; letter-spacing: 0.06em; text-transform: uppercase; }
.news-band h2 { margin: 0 0 10px; font-family: var(--serif); font-weight: 560; font-size: clamp(1.7rem, 3.2vw, 2.4rem); color: #fff; }
.news-band-head p { margin: 0; color: #CBE8F1; font-size: 1.05rem; line-height: 1.6; }
.news-band-list { list-style: none; margin: 0; padding: 0; display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 12px; }
.news-band-list a { display: block; height: 100%; padding: 16px 18px; border-radius: var(--radius-m); background: rgba(226, 244, 250, 0.07); border: 1px solid rgba(203, 232, 241, 0.18); color: #fff; text-decoration: none; transition: background .15s, border-color .15s; }
.news-band-list a:hover { background: rgba(34, 184, 214, 0.16); border-color: #22B8D6; }
.news-band-list b { display: block; font-family: var(--serif); font-weight: 560; font-size: 1.15rem; margin-bottom: 4px; }
.news-band-list span { color: #CBE8F1; font-size: 0.95rem; }
.news-band-more { margin: 24px 0 0; }
.news-band .btn { background: #22B8D6; color: #072F46; border-color: #22B8D6; }
.news-band .btn:hover { background: #fff; color: #072F46; border-color: #fff; }
@media (max-width: 1020px) { .news-band-list { grid-template-columns: repeat(2, minmax(0, 1fr)); } }
@media (max-width: 560px) { .news-band-list { grid-template-columns: minmax(0, 1fr); } }

/* Ιστορικό Αρχείο: σημείωση */
.archive-note { max-width: 46rem; margin: 0 0 28px; padding: 14px 18px; border-left: 3px solid var(--eosin); background: var(--hema-tint); border-radius: 0 var(--radius-s) var(--radius-s) 0; color: var(--ink); font-size: 0.98rem; }

/* Κεφαλίδα: χωράει το πλήρες μενού σε μία γραμμή */
@media (min-width: 1301px) {
  .site-header .wrap { max-width: 1320px; gap: 16px; }
  .brand-name { font-size: 1.14rem; }
  .nav > a, .nav-group > button { padding: 9px 8px; font-size: 0.93rem; }
  .nav .nav-cta { padding: 10px 14px; margin-left: 6px; }
}

/* ---------- Δημοσίευση NEJM: «πρώτη μούρη» ---------- */
.hero-grid.hero-pub { grid-template-columns: minmax(0, 1.35fr) minmax(0, 0.85fr); align-items: center; }
.pub-card {
  position: relative; background: var(--paper); border: 1px solid var(--line);
  border-top: 5px solid var(--hema-deep); border-radius: var(--radius-m);
  padding: 26px 28px 24px; box-shadow: 0 30px 60px -38px rgba(7, 47, 70, 0.45);
}
.pub-card::after { content: ""; position: absolute; left: 28px; right: 28px; top: 10px; border-top: 1px solid var(--hema-deep); opacity: .35; }
.pub-card p { margin: 0; }
.pub-card-kicker { color: var(--eosin); font-weight: 650; font-size: 0.8rem; letter-spacing: 0.08em; text-transform: uppercase; margin-top: 6px !important; }
.pub-card-journal { font-family: var(--serif); font-size: 1.12rem; font-weight: 600; color: var(--hema-deep); margin-top: 10px !important; padding-bottom: 14px; border-bottom: 1px solid var(--line); font-variant: small-caps; letter-spacing: 0.02em; }
.pub-card-title { font-family: var(--serif); font-style: italic; font-weight: 500; font-size: clamp(2rem, 3.6vw, 2.7rem); line-height: 1.05; color: var(--ink); margin: 18px 0 14px !important; }
.pub-card-ref { color: var(--ink-2); font-size: 0.95rem; line-height: 1.55; }
.pub-card-ref b { color: var(--hema-deep); }
.pub-card--wide { max-width: 34rem; margin-top: 26px; }
@media (max-width: 1020px) { .hero-grid.hero-pub { grid-template-columns: minmax(0, 1fr); } .pub-card { max-width: 30rem; } }

/* ---------- Χρώματα ενοτήτων για το κοινό ---------- */
.cat-sun  { --cc: #F29B30; --cc-ink: #8F4E00; --cc-tint: #FFF3E2; }
.cat-acne { --cc: #F07A5F; --cc-ink: #A2381F; --cc-tint: #FFEDE8; }
.cat-inf  { --cc: #3BAA74; --cc-ink: #1C6943; --cc-tint: #E5F6EC; }
.cat-std  { --cc: #7E6BD9; --cc-ink: #4A389F; --cc-tint: #EFECFB; }
.cat-chr  { --cc: #1FA7B8; --cc-ink: #0A6772; --cc-tint: #E0F5F7; }
.cat-hair { --cc: #D4A82A; --cc-ink: #765900; --cc-tint: #FBF4DD; }
.cat-dot { display: inline-block; width: 12px; height: 12px; border-radius: 50%; background: var(--cc); margin-right: 10px; vertical-align: 1px; box-shadow: 0 0 0 4px var(--cc-tint); }

/* Σελίδα «Πληροφορίες για ασθενείς»: κάθε ενότητα κάρτα με το χρώμα της */
.cat { background: var(--paper); border: 1px solid var(--line); border-top: 6px solid var(--cc); border-radius: var(--radius-m); padding: 22px 24px 8px; }
.cat h2 { color: var(--cc-ink); }
.cat ul { border-top-color: var(--cc-tint); }
.cat li:last-child { border-bottom: 0; }
.cat li a:hover strong { color: var(--cc-ink); }
.cat li a:hover { background: linear-gradient(90deg, var(--cc-tint), transparent 70%); }
.cat-grid { gap: 28px 28px; }

/* Αρχική: λίστα θεμάτων */
.topic-group h3 { border-bottom: 3px solid var(--cc); }
.topic-group li a:hover { color: var(--cc-ink); }

/* Άρθρα ασθενών: σήμα ενότητας και χρωματιστή γραμμή */
.page-head[class*="cat-"] h1 { padding-bottom: 14px; border-bottom: 4px solid var(--cc); display: inline-block; }
.cat-chip { display: inline-block; margin-left: 8px; padding: 3px 11px; border-radius: 999px; background: var(--cc-tint); color: var(--cc-ink) !important; font-weight: 600; font-size: 0.85rem; text-decoration: none; border: 1px solid var(--cc); }
.cat-chip:hover { background: var(--cc); color: #fff !important; }

/* Όνομα: πατρώνυμο και τίτλοι */
.brand-titles { font-family: var(--sans, inherit); font-size: 0.72em; font-weight: 600; letter-spacing: 0.02em; color: var(--ink-2); }
.hero h1 .h1-mid { font-size: 0.62em; font-style: italic; font-weight: 400; color: var(--eosin); letter-spacing: 0; }

@media (max-width: 560px) { .brand-name { white-space: normal; } .brand-titles { white-space: nowrap; } }
.bn, .brand-titles { white-space: nowrap; }
.hero h1 .h1-last { white-space: nowrap; }
.hero h1 .h1-mid { display: inline; }

/* Σύνδεσμοι δημοσιεύσεων */
.pub-link { display: inline-block; margin-left: 6px; padding: 1px 9px; border: 1px solid var(--line); border-radius: 999px; font-size: 0.8rem; font-weight: 600; text-decoration: none; color: var(--hema); background: var(--paper); white-space: nowrap; }
.pub-link:hover { background: var(--hema); color: #fff; border-color: var(--hema); }

/* Τονισμένο θέμα: Ισοτρετινοΐνη (HOT) */
.hot-badge { display: inline-block; margin-left: 8px; padding: 2px 8px 1px; border-radius: 999px; background: linear-gradient(135deg, #FF7A1A, #E8452C); color: #fff; font-family: var(--sans); font-size: 0.68rem; font-weight: 800; letter-spacing: 0.08em; vertical-align: 2px; box-shadow: 0 3px 10px -3px rgba(232, 69, 44, 0.6); }
.cat li.is-hot { background: linear-gradient(90deg, #FFF0E6, rgba(255,240,230,0) 85%); border-left: 3px solid #E8452C; margin-left: -12px; padding-left: 9px; border-radius: 0 6px 6px 0; }
.cat li.is-hot a strong { color: #A2381F; font-size: 1.08rem; }
.topic-group li.is-hot a { font-weight: 650; color: #A2381F; }
.cat li a strong .hot-badge { display: inline-block; color: #fff; font-size: 0.68rem; line-height: 1.5; margin-top: 0; }

/* Σεμνότερη έμφαση (αντί για «HOT») */
.hot-badge { background: var(--cc-tint, #FFEDE8); color: var(--cc-ink, #A2381F); border: 1px solid var(--cc, #F07A5F); box-shadow: none; font-weight: 650; font-size: 0.7rem; letter-spacing: 0.02em; padding: 1px 8px; }
.cat li a strong .hot-badge { color: var(--cc-ink); font-size: 0.72rem; }
.cat li.is-hot { background: linear-gradient(90deg, var(--cc-tint), transparent 80%); border-left: 3px solid var(--cc); }
.cat li.is-hot a strong { color: var(--cc-ink); font-size: 1.03rem; }
.topic-group li.is-hot a { font-weight: 600; color: var(--cc-ink); }

/* Αρχική: στήλη «Επιλεγμένα» (μικρή, ευανάγνωστη) */
.selected-work { list-style: none; margin: 0 0 22px; padding: 0; max-width: 34rem; border-top: 1px solid var(--line); }
.selected-work li { display: grid; grid-template-columns: 3.2rem minmax(0, 1fr); gap: 10px; padding: 11px 0; border-bottom: 1px solid var(--line); font-size: 0.95rem; line-height: 1.5; color: var(--ink-2); }
.selected-work .sw-y { font-weight: 650; color: var(--eosin); font-size: 0.88rem; padding-top: 1px; }
.selected-work i { color: var(--ink); }
.selected-work b { color: var(--hema-deep); font-weight: 650; }

/* Επιστημονικό έργο: μικρότερη κάρτα NEJM */
.pub-card--wide { max-width: 26rem; padding: 18px 22px 16px; margin-top: 20px; box-shadow: 0 18px 40px -30px rgba(7, 47, 70, 0.4); border-top-width: 4px; }
.pub-card--wide::after { left: 22px; right: 22px; top: 8px; }
.pub-card--wide .pub-card-kicker { font-size: 0.74rem; }
.pub-card--wide .pub-card-journal { font-size: 0.98rem; padding-bottom: 10px; margin-top: 6px !important; }
.pub-card--wide .pub-card-title { font-size: 1.55rem; margin: 12px 0 8px !important; }
.pub-card--wide .pub-card-ref { font-size: 0.88rem; }

/* Νέα άρθρα: φωτογραφίες με λεζάντα και αναφορά δημιουργού */
.prose .nfig { margin: 26px 0 30px; }
.prose .nfig > a { display: block; border-radius: var(--radius-m); overflow: hidden; background: var(--hema-tint); box-shadow: 0 18px 40px -28px rgba(7, 47, 70, 0.45); }
.prose .nfig img { display: block; width: 100%; height: auto; }
.prose .nfig.hero img { max-height: 520px; object-fit: cover; }
.prose .nfig figcaption { margin-top: 10px; font-size: 0.92rem; color: var(--ink-2); line-height: 1.5; }
.prose .nfig .credit { display: block; margin-top: 3px; font-size: 0.78rem; color: var(--muted); }
.prose .nfig .credit a { color: var(--muted); display: inline; background: none; box-shadow: none; border-radius: 0; }
.prose .nfig-row { display: grid; grid-template-columns: repeat(auto-fit, minmax(220px, 1fr)); gap: 18px; margin: 26px 0 30px; }
.prose .nfig-row .nfig { margin: 0; }
.prose .nfig-row .nfig img { aspect-ratio: 4 / 3; object-fit: cover; }

/* ---------- Ισοτρετινοΐνη (iso.html): γραφικά ---------- */
.prose .lead { font-size: 1.22rem; line-height: 1.7; color: var(--ink); }
.prose .lead::first-letter { font-size: 3.1em; float: left; line-height: 0.9; margin: 0.08em 0.1em 0 0; color: #A2381F; font-weight: 600; }
.iso-figsrc { display: block; font-family: var(--sans); font-size: 0.82rem; color: var(--muted); margin: 10px 0 0 !important; }
.iso-hint { display: block; font-family: var(--sans); font-size: 0.9rem; color: #A2381F; margin-top: 0.4em; }

.iso-stats { display: grid; grid-template-columns: repeat(4, 1fr); gap: 10px; margin: 1.6em 0 1.8em; font-family: var(--sans); }
.iso-stats > div { background: #FFEDE8; border: 1px solid #F7C4B6; border-radius: var(--radius-m); padding: 14px 12px 12px; text-align: center; }
.iso-stats b { display: block; font-size: 1.7rem; line-height: 1.1; color: #A2381F; font-weight: 750; letter-spacing: -0.01em; }
.iso-stats span { display: block; font-size: 0.82rem; line-height: 1.35; color: var(--ink-2); margin-top: 6px; }

.iso-pillars { display: grid; grid-template-columns: 1fr 1fr; gap: 14px; margin: 0.4em 0 1.4em; font-family: var(--sans); }
.iso-pillar { position: relative; background: var(--paper); border: 1px solid var(--line); border-top: 5px solid #F07A5F; border-radius: var(--radius-m); padding: 18px 18px 8px 64px; }
.iso-pnum { position: absolute; left: 16px; top: 16px; width: 34px; height: 34px; border-radius: 50%; background: #A2381F; color: #fff; display: grid; place-items: center; font-weight: 700; }
.prose .iso-pillar h3 { font-family: var(--sans); font-size: 1.05rem; margin: 0 0 4px; color: #A2381F; }
.prose .iso-pillar p { font-size: 0.95rem; line-height: 1.55; }

.iso-mech { display: grid; grid-template-columns: 240px 1fr; gap: 22px; align-items: center; margin: 1.2em 0 1.6em; background: var(--paper); border: 1px solid var(--line); border-radius: var(--radius-m); padding: 18px; }
.iso-mech svg { width: 100%; height: auto; display: block; border-radius: 8px; }
.prose .iso-mech-list { list-style: none; padding: 0; margin: 0; counter-reset: m; font-family: var(--sans); }
.prose .iso-mech-list li { counter-increment: m; position: relative; padding: 0 0 12px 44px; margin: 0; }
.iso-mech-list li::before { content: counter(m); position: absolute; left: 0; top: 0; width: 30px; height: 30px; border-radius: 50%; background: #A2381F; color: #fff; font-weight: 700; display: grid; place-items: center; font-size: 0.95rem; }
.iso-mech-list b { display: block; font-size: 1.02rem; color: var(--ink); }
.iso-mech-list span { display: block; font-size: 0.93rem; line-height: 1.5; color: var(--ink-2); }

.iso-dose { margin: 1.4em 0 1.8em; background: var(--paper); border: 1px solid var(--line); border-radius: var(--radius-m); padding: 18px 20px; font-family: var(--sans); }
.iso-dose-head b { display: block; font-size: 1.1rem; color: #A2381F; }
.iso-dose-head span { display: block; font-size: 0.9rem; color: var(--ink-2); margin: 2px 0 14px; line-height: 1.45; }
.iso-bar { display: grid; grid-template-columns: 150px 1fr; gap: 12px; align-items: center; margin: 9px 0; }
.iso-bar-lab b { display: block; font-size: 0.95rem; }
.iso-bar-lab span { display: block; font-size: 0.78rem; color: var(--muted); }
.iso-bar-track { position: relative; height: 30px; background: #F7F1EF; border-radius: 6px; }
.iso-bar-fill { height: 100%; border-radius: 6px; background: linear-gradient(90deg, #F07A5F, #D9573A); min-width: 6px; }
.iso-bar:last-of-type .iso-bar-fill { background: repeating-linear-gradient(45deg, #C9B3AC, #C9B3AC 8px, #D9C6C0 8px, #D9C6C0 16px); }
.iso-bar-val { position: absolute; top: 50%; transform: translateY(-50%); left: 10px; font-size: 0.85rem; font-weight: 700; color: #fff; text-shadow: 0 1px 2px rgba(0,0,0,.25); white-space: nowrap; }
.iso-bar:first-of-type .iso-bar-val { left: calc(16.7% + 8px); color: var(--ink); text-shadow: none; }

.iso-meal { display: grid; grid-template-columns: 130px 1fr; gap: 18px; align-items: center; background: #FFF6E5; border: 1px solid #F2D49B; border-left: 6px solid #F29B30; border-radius: var(--radius-m); padding: 16px 18px; margin: 0.8em 0 1.2em; }
.iso-meal-big { text-align: center; font-family: var(--sans); }
.iso-meal-big b { display: block; font-size: 2.4rem; line-height: 1; color: #8F4E00; font-weight: 750; }
.iso-meal-big span { display: block; font-size: 0.82rem; color: #8F4E00; margin-top: 4px; }
.prose .iso-meal h3 { margin: 0 0 4px; font-family: var(--sans); font-size: 1.05rem; color: #8F4E00; }
.prose .iso-meal p { margin: 0; font-size: 0.98rem; line-height: 1.6; }

.prose .iso-steps { list-style: none; padding: 0; margin: 1em 0 1.4em; display: grid; grid-template-columns: repeat(3, 1fr); gap: 12px; counter-reset: s; font-family: var(--sans); }
.prose .iso-steps li { counter-increment: s; background: var(--paper); border: 1px solid var(--line); border-radius: var(--radius-m); padding: 14px 14px 12px; margin: 0; position: relative; }
.iso-steps li::before { content: counter(s); display: grid; place-items: center; width: 26px; height: 26px; border-radius: 50%; background: var(--hema); color: #fff; font-weight: 700; font-size: 0.85rem; margin-bottom: 8px; }
.iso-steps b { display: block; font-size: 0.98rem; color: var(--hema-deep); }
.iso-steps span { display: block; font-size: 0.9rem; line-height: 1.5; color: var(--ink-2); margin-top: 3px; }

.iso-alert { background: #FDECEC; border: 1px solid #F1B9B9; border-left: 6px solid #C62828; border-radius: var(--radius-m); padding: 16px 18px 6px; margin: 1em 0 1.2em; }
.iso-alert-nums { display: grid; grid-template-columns: 1fr 1fr; gap: 12px; font-family: var(--sans); margin-bottom: 10px; }
.iso-alert-nums b { display: block; font-size: 2rem; line-height: 1.05; color: #B71C1C; font-weight: 750; }
.iso-alert-nums span { display: block; font-size: 0.86rem; color: #6B2020; line-height: 1.4; }
.prose .iso-alert p { font-size: 1rem; margin-bottom: 0.8em; }

.iso-tl { margin: 0.6em 0 1.2em; font-family: var(--sans); }
.iso-tl-row { display: grid; grid-template-columns: 1fr 1.6fr 1fr 1.3fr; border-radius: var(--radius-m); overflow: hidden; border: 1px solid var(--line); }
.iso-tl-seg { padding: 12px 12px 10px; font-size: 0.85rem; line-height: 1.35; }
.iso-tl-seg b { display: block; font-size: 0.95rem; margin-bottom: 2px; }
.iso-tl-seg.pre { background: #EFECFB; color: #4A389F; }
.iso-tl-seg.on { background: #F07A5F; color: #fff; }
.iso-tl-seg.post { background: #EFECFB; color: #4A389F; }
.iso-tl-seg.ext { background: repeating-linear-gradient(45deg, #E4DEFA, #E4DEFA 8px, #F3F0FD 8px, #F3F0FD 16px); color: #4A389F; }

.iso-side { display: grid; grid-template-columns: 1fr 1fr; gap: 14px; margin: 1em 0 1.4em; font-family: var(--sans); }
.iso-side-col { border-radius: var(--radius-m); padding: 16px 18px 6px; border: 1px solid var(--line); background: var(--paper); }
.iso-side-col.ok { border-top: 5px solid #3BAA74; }
.iso-side-col.warn { border-top: 5px solid #C62828; background: #FFF8F8; }
.prose .iso-side-col h3 { font-family: var(--sans); font-size: 1.05rem; margin: 0 0 8px; }
.iso-side-col.ok h3 { color: #1C6943; }
.iso-side-col.warn h3 { color: #B71C1C; }
.prose .iso-side-col ul { padding-left: 1.1em; }
.prose .iso-side-col li { font-size: 0.93rem; line-height: 1.5; margin-bottom: 0.6em; }

.iso-myths { margin: 1em 0 1.6em; }
.iso-myth { background: var(--paper); border: 1px solid var(--line); border-radius: var(--radius-m); margin: 0 0 10px; overflow: hidden; }
.iso-myth[open] { border-color: #F7C4B6; box-shadow: 0 2px 12px rgba(162,56,31,.07); }
.iso-myth summary { cursor: pointer; list-style: none; display: grid; grid-template-columns: auto 1fr auto; gap: 12px; align-items: center; padding: 14px 16px; font-family: var(--sans); }
.iso-myth summary::-webkit-details-marker { display: none; }
.iso-myth summary::after { content: "+"; grid-column: 3; grid-row: 1; justify-self: end; font-size: 1.3rem; color: #A2381F; width: 24px; text-align: center; }
.iso-myth[open] summary::after { content: "−"; }
.iso-myth-tag { background: #A2381F; color: #fff; font-size: 0.72rem; font-weight: 700; letter-spacing: .06em; text-transform: uppercase; padding: 3px 8px; border-radius: 4px; }
.iso-myth-q { font-weight: 600; font-size: 1rem; line-height: 1.4; color: var(--ink); }
.iso-myth-v { grid-column: 2; font-size: 0.8rem; font-weight: 650; color: #1C6943; background: #E5F6EC; border-radius: 999px; padding: 2px 10px; justify-self: start; }
.iso-myth-a { padding: 0 18px 8px; border-top: 1px dashed var(--line); }
.prose .iso-myth-lab { font-family: var(--sans); font-size: 0.78rem; font-weight: 700; letter-spacing: .06em; text-transform: uppercase; color: #1C6943; margin: 14px 0 6px; }
.prose .iso-myth-a p { font-size: 1.02rem; }
.prose .iso-key { background: #E5F6EC; border-radius: 8px; padding: 10px 14px; }
.iso-dosedep { display: grid; grid-template-columns: 1fr 1.4fr; gap: 10px; margin: 0.4em 0 1.1em; font-family: var(--sans); }
.iso-dosedep > div { border-radius: 8px; padding: 10px 12px; }
.iso-dosedep > div:first-child { background: #FFF3E2; }
.iso-dosedep > div:last-child { background: #E5F6EC; }
.prose .iso-dosedep h4 { margin: 0 0 4px; font-size: 0.86rem; }
.prose .iso-dosedep p { margin: 0; font-size: 0.9rem; line-height: 1.5; }
.iso-quote { margin: 1.2em 0; padding: 4px 0 4px 20px; border-left: 4px solid #F07A5F; font-style: italic; color: var(--ink-2); }

.iso-position { position: relative; background: var(--hema-tint); border-radius: var(--radius-m); padding: 22px 22px 10px 22px; margin: 1em 0 1.4em; }
.iso-position::before { content: "“"; position: absolute; right: 18px; top: -18px; font-family: var(--serif); font-size: 6rem; line-height: 1; color: var(--hema); opacity: .18; }
.prose .iso-sign { font-family: var(--sans); font-weight: 650; color: var(--hema-deep); text-align: right; }

.iso-concl { background: linear-gradient(135deg, #FFEDE8, #FFF7F3); border: 1px solid #F7C4B6; border-radius: var(--radius-m); padding: 20px 22px; margin: 1em 0 1.4em; }
.prose .iso-concl p { font-size: 1.12rem; }
.prose .iso-concl .btn { color: #fff; text-decoration: none; }

@media (max-width: 720px) {
  .iso-stats { grid-template-columns: 1fr 1fr; }
  .iso-pillars, .iso-side, .iso-dosedep, .prose .iso-steps { grid-template-columns: 1fr; }
  .iso-mech { grid-template-columns: 1fr; }
  .iso-mech svg { max-width: 240px; margin: 0 auto; }
  .iso-bar { grid-template-columns: 100px 1fr; }
  .iso-tl-row { grid-template-columns: 1fr; }
  .iso-meal { grid-template-columns: 1fr; text-align: left; }
  .iso-meal-big { text-align: left; }
  .iso-alert-nums { grid-template-columns: 1fr; }
}
@media print { .iso-myth .iso-myth-a { display: block; } }